Endocrine Abstracts

Introduction: Regardless of the fact that the incidence of thyroid cancer has increased significantly in recent years, the simultaneous occurrence of multiple tumors in one thyroid gland is still a rare phenomenon. These tumors have the morphology, either of a single mass with mixed histological features, or of a single lesion consisting of two distinct cell-populations, or of two different tumors between which normal thyroid tissue is interposed. Various theories have been pr...

Background: Adrenal incidentalomas (AI) have an increasing prevalence during last decades, probably due to the extended use of new imaging techniques and longer life expectancy. Adrenal hormonal hypersecretion, even subclinical, is probably related to cardiovascular disease (CVD).Methods: We evaluated 100 patients with adrenal masses, incidentally discovered in imaging techniques performed for non adrenal disorders (67 Female, 33 Male, mean 58.1±12....

Introduction: Adrenal Cushing’s syndrome accounts for 15-20% of all the causes of endogenous hypercortisolism, mainly due to unilateral adenomas and adrenal cancer. Approximately 9-17% of patients with ACTH-independent Cushing’s syndrome have bilateral adrenal adenomas. Subsequently, their management is quite demanding. The main difficulty lies in distinguishing between a functional and a non-functional adrenal mass, since this cannot be reliably achieved by routine ...

Introduction: Effective gestational diabetes mellitus (GDM) management is pivotal for reducing delivery complications for both mother and offspring, since a linear and continuous association between blood glucose and unfavorable outcomes has been extensively reported. The aim of present study was to investigate possible factors affecting GDM treatment goals.Methods: We retrospectively evaluated 136 consecutive patients with GDM, treated in our department...

Introduction: Effective acromegaly treatment in the era of somatostatin analog therapy may initially seem easy to apply. Several factors, modifiable or not, may be involved in every patient’s treatment. The aim of this study was to evaluate possible factors affecting effective acromegaly treatment.Methods: From the original pool of 25 patients, that were diagnosed with acromegaly in our department during the last 15 years, 18 are currently being fol...

Introduction: Recent advances in energy homeostasis revealed a significant interconnection between bone and adipose tissue through osteocalcin. Reduced bone mass documented in type 1 diabetes mellitus (T1D) could be related to disregulation of adipokine signaling on bone.Materials and Methods: We evaluated 40 children and adolescents with T1D (mean±S.D. age 13.04±3.53 years, mean±S.D. T1D duration 5.15±3....

Introduction: Pembrolizumab is a programmed death receptor-1(PD-1)-blocking antibody, used in a variety of advanced malignant tumors with promising results, although adverse events are not rare.Case report: We present the case of an adult female, with negative personal and family history of autoimmune diseases, who developed malignant superficial melanoma of right wrist 6 years ago. She was initially treated with surgical resection (lesion and ipsilatera...

Introduction: T1DM is a risk factor for reduced bone mass, disrupting several bone metabolic pathways. Dickkopf-1 is an inhibitor of the Wnt/b-catenin bone metabolic pathway. Increased fracture risk and elevated Dickkopf-1 levels have been documented in adult patients with T2DM. No relevant data exist on childhood T1DM. Our aim was to study plasma Dickkopf-1 concentration in children and adolescents with T1DM and controls and to correlate Dickkopf-1 levels with metabolic bone ...

Introduction: Parathyroid adenoma is the most common cause of primary hyperparathyroidism (PHPT) resulting in hypercalcemia and hypercalciuria due to autonomous secretion of PTH. Ectopic parathyroid adenoma, as a consequence of variability in the glandular tissue migration during the embryologic life or a supernumary fifth parathyroid gland, has an incidence of 25% among patients with PHPT. The incidence of deeply mediastinal ectopic parathyroid adenoma is 1–3%.<p cla...

Introduction: Sclerostin is an inhibitor of the Wnt/β-catenin bone metabolic pathway. Increased sclerostin levels and reduced bone mineral density (BMD) have been documented in adult patients with diabetes mellitus (DM), predominantly in those with type 2 diabetes mellitus (T2DM). No relevant data exist on childhood T1DM. Our aim was to study plasma sclerostin concentration in children and adolescents with T1DM and controls and to correlate sclerostin levels with metaboli...